The FDA just shot down a new rheumatoid arthritis drug (INCY, LLY)

rheumatoid arthritisdavid__jones/Flickr Creative Commons

The FDA just rejected a new daily pill to treat rheumatoid arthritis.

Pharmaceutical companies Lilly and Incyte said on Friday that their drug, baricitinib, had been issued a complete response letter, which explains why the drug didn’t get approval. 

In its letter, the FDA told Lilly and Incyte that it wanted more data on what the right dose for the drug is.  The FDA also wants more data about potential safety issues.

The FDA had previously pushed back its review date of baricitinib by three months. Even so, analysts largely expected the FDA to approve baricitinib, especially after the European Commission approved the drug in February. If approved would have been a competitor to Pfizer’s Xeljanz. 

“We are disappointed with this action. We remain confident in the benefit/risk of baricitinib as a new treatment option for adults with moderate-to-severe RA,” Christi Shaw, Lilly Bio-Medicines president said in a news release. The companies plan to resubmit the drug to the FDA.

Rheumatoid arthritis is a common, chronic inflammatory condition that affects the joints. There are a number of ways to treat the disease, such as the chemotherapy drug methotrexate.

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Russia will boycott this year’s Eurovision song contest over an argument with Ukraine

Sergey Lazarev Russia EurovisionTT News Agency/Maja Suslin/via REUTERS

MOSCOW (Reuters) – Russia’s state broadcaster has said it will boycott this year’s Eurovision song contest after the host country, Ukraine, said it would bar entry to the Russian contestant and Moscow rejected two possible compromises suggested by organizers.

Ukraine said Russian singer Yulia Samoylova could not travel to Kiev for the competition because she had performed in Crimea after the region was annexed by Russia.

Moscow accused Ukraine of discriminating against Samoylova and of breaching the contest’s rules.

Russia’s Channel One, the state broadcaster that transmits the contest to large Russian audiences, said organizers had offered the option of sending a different contestant or of having Samoylova perform via video link from Moscow.

“In our view this represents discrimination against the Russian entry, and of course our team will not under any circumstances agree to such terms,” said Yuri Aksyuta, the station’s chief producer for musical and entertainment programs.

“Naturally, we are not taking part in the Eurovision 2017 competition under the terms that are being offered to us, and we will not broadcast it either,” he said.

“The absence of a Russian participant, in my view, is a very serious blow to the reputation of the contest itself, and for Russian viewers it is also another reason not to pay attention to the contest.”

(Reporting by Christian Lowe; Editing by Andrew Osborn)

Unpkg.com hacked?

I’ve checked on both my local machine and on a VPS I run, and the following URL is 302 redirecting to a malicious JS script which pops up a confirmation window and then redirects to ads:

SOURCE URL: https://unpkg.com/react@latest/dist/react.js

MALICIOUS REDIRECT: https://compliance-jessica.xyz/a.php

This is the URL recommended for in-browser development use by https://facebook.github.io/react/docs/installation.html

Can anyone else replicate this?

Scientists have discovered 5 traits linked with a longer, happier life

london scout unsplashUnsplash/London Scout

We tend to think of successful people – even the ones who inherit their status – as being born with grit.

Traits like that, we’re told, will drive us to early prosperity and set us up for happiness later on.

A new study of more than 8,000 men and women over 50 suggests that’s probably not true. Instead, traits like grit and optimism can be learned, and they keep playing an important role in our health and happiness long after we land our first job, the study found.

The findings of the new paper are bolstered by decades of previous research linking well-being and longevity to characteristics like optimism. Read on to see which ones you possess.

Conscientiousness

Unsplash / Joshua Earle

In the most recent study, published Monday in the journal Proceedings of the National Academy of Sciences, researchers linked conscientiousness, or being thorough and efficient but less likely to take risks, with increased well-being and happiness, along with 4 other traits. Of the more than 8,000 participants in the study, only 23% were defined as conscientious.

Other research ties conscientiousness with well-being. A 75-year analysis of 300 couples who enrolled in the study in their mid-20s while engaged found that men whom their friends identified as conscientious tended to live longer than those who were not seen as possessing the trait. Another long-term study came to similar conclusions, but this time about men and women. Members of both gender who were seen as conscientious lived longer, on average, than their non-conscientious peers.

Optimism

Unsplash/London Scout

To measure optimism in the most recent study, researchers asked participants to rank how much they agreed with the following two statements: 1) “I feel that life is full of opportunities,” and 2) “I feel that the future looks good for me.” Using those measures, roughly a quarter of participants were identified as optimistic.

In the past, researchers have noted links between optimism and good health, even when accounting for differences in people’s socioeconomic status. A recent German study of roughly 2,500 people found that psychological resources like optimistic personal beliefs positively affected participants’ health across incomes and education levels.

Grit

Scott Olson/Getty Images

Under 21% of the people in the most recent study were identified as having grit or being determined, making it the rarest out of the 5 life skills outlined in the study.


See the rest of the story at Business Insider

Ask HN: How to deal with anxiety around wasting time?

Hi guys, I’m a pathological hoarder. Be it karma points to books, I have a serious issue where if I’m not allowed to hoard digitally, it makes me uneasy.

However, the bigger problem is trying to consume what I’ve hoarded. I know there are urgent topics that I discovered on HN that I’ve raised multiple flags for me to spend time reading (because of it’s potential ROI) but failed to because

If it doesn’t seem like work it seems like a waste of time and if it seems like work it seems like I should be resting.

Meaning, there is a real anxiety around doing anything but work. When I try to get into a good book or an article, the panic starts to set in and I get an overwhelming urge to stop and do something that I perceive to be work related.